Think of the NuCalm Disc like a battery. A battery contains a charge; once it touches a metal contact, that device begins pulling energy from it. Similarly, the Disc contains signaling to activate the GABAergic system; once it touches your skin, your body begins pulling frequencies from it.
The Pericardium 6 acupressure point on your left arm contains a direct Meridien connection to the Pericardium sac which contains your heart. The frequencies of GABA and L-Theanine travel through your arm, to your heart, which sends the message to your brain to relax. This interrupts the adrenaline response, allowing the NuCalm "music" software to slow your brainwave frequency.
The Disc does not contain any chemicals that pass through the skin. It is not transdermal.